Circ_0026359 induces HOXA9 to regulate gastric cancer malignant progression through miR-140-3p

Abstract Recent researches indicate the key role of circRNA in gastric cancer (GC) progression. However, circ_0026359 GC progression remains unclear. This study aims to analyze development and underlying mechanism. The results showed that compared with controls, tissues cells displayed high HOXA9 expression, low miR-140-3p expression. Depletion repressed cell proliferation, migration, invasion glycolysis, induced apoptosis. Circ_0026359 knockdown inhibited neoplasm growth vivo. Under-expression miR-140-3p, a target miRNA circ_0026359, relieved effects on Additionally, was regulated by circ_0026359/miR-140-3p axis. Thus, absence miR-140-3p/HOXA9 pathway, which provided an effective therapeutic for GC.